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Psychiatric disorders in low birthweight young adults. Prevalence and association with assessments at 11 years
I B Elgen1, F Holsten, M D Odberg
1Department of Clinical Medicine, University of Bergen, Bergen, Norway; Department of Child and Adolescent Psychiatry, Haukeland University Hospital, Norway; Department of Pediatric, Haukeland University Hospital, Norway.
Insights
Young adults born with low birthweight (LBW) face a significantly higher risk of developing psychiatric disorders, with only half remaining mentally healthy through adolescence.
Area of Science:
- Developmental Psychology
- Neuroscience
- Public Health
Background:
- Low birthweight (LBW), defined as less than 2,000 grams, is a significant risk factor for adverse developmental outcomes.
- Understanding the long-term mental health trajectories of individuals born with LBW is crucial for early intervention and support.
Purpose of the Study:
- To compare the mental health status of young adults born with moderate low birthweight (LBW) to those born with normal birthweight (NBW).
- To assess the prevalence of psychiatric disorders in LBW young adults and track their mental health throughout adolescence.
Main Methods:
- A cohort study involving 136 young adults with moderate LBW and 132 with NBW.
- Psychiatric assessments using the Mini-International Neuropsychiatric Interview (MINI) at age 19 and Children Assessment Schedule (CAS) at age 11.
Main Results:
- At 19 years, 32% of LBW young adults had a psychiatric disorder, compared to 10% of NBW individuals (OR: 2.8).
- Common disorders in the LBW group included affective, anxiety, ADHD, and antisocial personality disorders; 20% had multiple diagnoses.
- Only 56% of LBW individuals remained mentally healthy throughout adolescence, half the rate of controls.
Conclusions:
- Moderate LBW is associated with a substantially increased risk of psychiatric disorders in young adulthood.
- A significant proportion of LBW individuals experience mental health challenges during adolescence and young adulthood.
Objective:
To compare mental health of 136 young adults without neurosensory handicaps born with low birthweight (LBW, birthweight less than 2,000 g) with 132 adults with normal birthweight (NBW).
Method:
A cohort of moderate LBW and NBW young adults were assessed with the Mini-International Neuropsychiatric Interview (MINI) at 19 years and the Children Assessment Schedule (CAS) at 11 years of age.
Results:
At 19 years of age, 44 out of 136 (32%) LBW young adults were diagnosed with a psychiatric disorder compared to 10% NBW (OR: 2.8; 95% CI: 1.1, 4.5, P=0.02). Among the LBW young adults, affective-, anxiety-, ADHD- and antisocial personality disorders were most common, and nine subjects (20%) had more than one diagnosis. Of 97 LBW subjects examined both at 11 and 19 years of age, 54 (56%) were mentally healthy though out adolescence. This was half as many as for controls (OR: 0.6; 95% CI: 0.3 to 0.9).
Conclusion:
Moderate LBW was associated with an increased risk of psychiatric disorders in young adulthood. Only half of LBW young adults stayed healthy throughout adolescence.
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