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Comprehensive Endovascular and Open Surgical Management of Cerebral Arteriovenous Malformations
Published on: October 20, 2017
The problem with asymptomatic cerebral embolic complications in vascular procedures: what if they are not
1Department of Neurology, University of Virginia, Charlottesville, Virginia 22908, USA. drg3k@virginia.edu
Insights
Cerebral embolic events, often silent, are complications of vascular procedures. These silent infarcts contribute to cognitive decline and dementia, affecting hundreds of thousands annually.
Area of Science:
- Neurology
- Cardiovascular Medicine
- Vascular Surgery
Background:
- Cerebral embolic events are linked to carotid and cardiac disease.
- These events are increasingly recognized as complications of vascular procedures.
- Subclinical embolic events, or silent infarcts, are a growing concern.
Purpose of the Study:
- To highlight the clinical significance of cerebral embolic events.
- To underscore the link between silent infarcts and cognitive decline.
- To estimate the annual incidence of new brain injury in the US.
Main Methods:
- Literature review of recent reports and magnetic resonance imaging studies.
- Analysis of data on cognitive decline and dementia related to silent infarcts.
- Estimation of patient numbers affected by new brain injury annually.
Main Results:
- Silent infarcts are associated with memory loss, cognitive decline, and dementia.
- An estimated 600,000 patients in the US experience new brain injury annually.
- The impact of accelerated cognitive loss in at-risk populations may be significant.
Conclusions:
- Cerebral embolic events, particularly silent ones, pose a significant threat to cognitive health.
- The high incidence of new brain injury warrants further clinical attention.
- Understanding and mitigating silent infarcts is crucial for preventing premature cognitive decline.
Abstract:
Cerebral embolic events related to carotid and cardiac disease have been known for decades. Recently, cerebral embolic events have become a focus of clinical importance as complications of vascular procedures. Further, the development of new technologies and procedures has increased the overall clinical significance. Although the relative safety of these procedures is usually defined by acute stroke risk, it is also becoming clear that far more subclinical events are occurring. Recent reports provided substantial evidence of memory loss, cognitive decline, and dementia related to these so-called silent infarcts. Literature reports of magnetic resonance imaging events lead to an estimate of as many as 600,000 patients with new brain injury each year in the United States alone. Given the magnitude of the numbers involved, the impact of accelerated cognitive loss and premature senescence in a vulnerable at-risk population could well be significant.
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