Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

COPD: Management Using Bronchodilators and Corticosteroids

COPD: Management Using Bronchodilators and Corticosteroids

Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...

Chronic Obstructive Pulmonary Disease-I: Introduction

Chronic Obstructive Pulmonary Disease-I: Introduction

Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.

Chronic Obstructive Pulmonary Disease-V: Management

Chronic Obstructive Pulmonary Disease-V: Management

Managing Chronic Obstructive Pulmonary Disease (COPD) involves a multifaceted approach to reduce symptoms, prevent exacerbations, improve overall health status, and slow disease progression. Key strategies include lifestyle modifications, pharmacotherapy, supportive therapies, and, in some cases, surgery. Here is an overview of the primary COPD management strategies:
Smoking Cessation

Exercise and Cardiovascular Response

Exercise and Cardiovascular Response

Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History

Chronic Obstructive Pulmonary Disease

Chronic Obstructive Pulmonary Disease

COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A mutation in PTPN6 associated to emphysema alters B-lymphocyte biology in humans and mice.

Journal of immunology (Baltimore, Md. : 1950)·2026

Same author

Evaluating the feasibility and preliminary effects of a group-based telerehabilitation program in individuals with persistent dyspnea after COVID-19 (TEPCO): a pilot randomized controlled study.

Pilot and feasibility studies·2026

Same author

Dyspnea and Sleep Apnea: Sharing the Same Bed?

Chest·2026

Same author

A pragmatic assessment of the influence of data processing on Bluetooth oximetry in pulmonary rehabilitation.

Respiratory medicine·2026

Same author

Reducing Inhaler Waste and Costs Through Sustainable Interventions.

Chest·2026

Same author

The Potential of Chronic Hypoxia Biomarkers to Guide Home Oxygen Therapy Prescription in COPD.

Respiratory care·2026

Search research articles

Related Experiment Video

Updated: May 18, 2026

Home-Based Prescribed Pulmonary Exercise in Patients with Stable Chronic Obstructive Pulmonary Disease

Home-Based Prescribed Pulmonary Exercise in Patients with Stable Chronic Obstructive Pulmonary Disease

Published on: August 24, 2019

Walking exercise response to bronchodilation in mild COPD: a randomized trial.

Philippe Gagnon¹, Didier Saey, Steeve Provencher

¹Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie de Québec, 2725 Chemin Ste-Foy Québec, Université Laval, Québec G1V 4G5, Canada. philippe.gagnon@criucpq.ulaval.ca

Respiratory Medicine

|September 25, 2012

Summary

Bronchodilation did not improve walking endurance in patients with mild chronic obstructive pulmonary disease (COPD). While it offered minor physiological benefits like reduced breathing rate, these did not translate to meaningful improvements in exercise capacity.

More Related Videos

Dual Test Gas Pulmonary Diffusing Capacity Measurement During Exercise in Humans Using the Single-Breath Method

Dual Test Gas Pulmonary Diffusing Capacity Measurement During Exercise in Humans Using the Single-Breath Method

Published on: February 2, 2024

Related Experiment Videos

Last Updated: May 18, 2026

Home-Based Prescribed Pulmonary Exercise in Patients with Stable Chronic Obstructive Pulmonary Disease

Home-Based Prescribed Pulmonary Exercise in Patients with Stable Chronic Obstructive Pulmonary Disease

Published on: August 24, 2019

Dual Test Gas Pulmonary Diffusing Capacity Measurement During Exercise in Humans Using the Single-Breath Method

Dual Test Gas Pulmonary Diffusing Capacity Measurement During Exercise in Humans Using the Single-Breath Method

Published on: February 2, 2024

Area of Science:

Pulmonary Medicine
Respiratory Physiology

Background:

Patients with mild chronic obstructive pulmonary disease (COPD) exhibit abnormal ventilatory mechanics during exercise.
Bronchodilator therapy is often considered, but its efficacy in improving exercise tolerance, particularly walking, remains under investigation.

Purpose of the Study:

To assess the impact of bronchodilation on exercise tolerance in mild COPD patients during a shuttle walking test.
To evaluate changes in cardiopulmonary response and dynamic hyperinflation post-bronchodilation.

Main Methods:

A randomized, double-blind, cross-over trial involving 37 patients with GOLD stage I COPD.
Participants completed an endurance shuttle walking test after receiving either placebo or ipratropium bromide/salbutamol combination.

Main Results:

Bronchodilation significantly increased forced expiratory volume in 1 second (FEV1) compared to placebo.
No statistically significant difference in walking endurance time was observed between bronchodilation and placebo.
A trend towards a deeper, slower breathing pattern and significant effects on dynamic hyperinflation were noted.

Conclusions:

Bronchodilation does not enhance walking endurance in individuals with mild COPD.
Observed physiological benefits are minor and their clinical relevance is uncertain.