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Published on: January 5, 2024
Purine metabolites in fibromyalgia syndrome
1Dipartimento di Scienze della Vita e dell'Ambiente, Università di Cagliari, 09042 Monserrato, Cagliari, Italy.
Objective:
To evaluate serum purine metabolite concentrations in patients affected by fibromyalgia syndrome (FMS) and the relationships between their levels and FM clinical parameters.
Design And Methods:
Serum purine levels were quantified using LC/UV-vis in 22 fibromyalgic females (according to the American College of Rheumatology classification criteria) and 22 healthy females.
Results:
Significantly higher serum inosine, hypoxanthine and xanthine levels (p<0.001) and significantly lower serum adenosine (p<0.05) were detected in the FMS patients vs healthy controls. Our data show a negative correlation between adenosine and Fibromyalgia Impact Questionnaire (FIQ).
Conclusions:
Study results suggest that purines, in particular adenosine and inosine, may be involved in pain transmission in fibromyalgia.
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