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Thymidine glycol: the effect on DNA molecular structure and enzymatic processing

Nina G Dolinnaya1, Elena A Kubareva, Elena A Romanova

  • 1Department of Chemistry and Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 1 Leninskie Gory, 119991 Moscow, Russia.

Biochimie
|September 25, 2012
PubMed
Summary

Thymine glycol (Tg), a DNA oxidation product, significantly blocks DNA polymerases and is lethal in vivo. Its stereochemistry and DNA interactions are crucial for understanding DNA processing and repair.

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