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Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
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Targeting the TGFβ signalling pathway in disease

Rosemary J Akhurst1, Akiko Hata

  • 1Helen Diller Family Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California 94158, USA. RAkhurst@cc.ucsf.edu

Nature Reviews. Drug Discovery
|September 25, 2012
PubMed
Summary

Transforming growth factor-β (TGFβ) inhibitors show promise in treating fibrosis, cancer, and Marfan syndrome. Personalized dosing and monitoring are key to overcoming challenges in anti-TGFβ therapy.

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