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Related Experiment Videos

Racial differences in susceptibility to infection by Mycobacterium tuberculosis.

W W Stead1, J W Senner, W T Reddick

  • 1Tuberculosis Program, Arkansas Department of Health, Little Rock 72205-3867.

The New England Journal of Medicine
|February 15, 1990
PubMed
Summary
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Black individuals show a higher susceptibility to Mycobacterium tuberculosis infection, nearly twice that of white individuals. However, racial disparities do not influence the progression from infection to active tuberculosis disease.

Area of Science:

  • Infectious Diseases
  • Epidemiology
  • Public Health

Background:

  • Tuberculosis (TB) prevalence is disproportionately higher in Black populations compared to White populations.
  • Existing disparities suggest potential racial differences in susceptibility to Mycobacterium tuberculosis (M. tuberculosis) infection.

Purpose of the Study:

  • To investigate whether racial differences in susceptibility contribute to the disparity in tuberculosis infection rates.
  • To compare M. tuberculosis infection rates between Black and White individuals in racially integrated nursing homes.

Main Methods:

  • A cohort study involving 25,398 initially tuberculin-negative residents across 165 nursing homes.
  • New infection defined by a significant increase in tuberculin skin test induration (≥12 mm) after a negative two-step test.

Related Experiment Videos

  • Analysis of infection rates based on resident race and race of the source patient, including data from prison outbreaks.

    • Main Results:

    • Black residents exhibited a higher rate of new M. tuberculosis infection (13.8%) compared to White residents (7.2%), with a relative risk of 1.9.
    • Higher infection rates in Black individuals were observed regardless of the source patient's race.
    • No significant racial difference was found in the progression from M. tuberculosis infection to clinical tuberculosis.

    Conclusions:

    • Black individuals are more readily infected by M. tuberculosis than White individuals.
    • Susceptibility to M. tuberculosis infection appears to be independent of factors influencing the progression to clinical disease.