Related Experiment Video
Updated: May 18, 2026
10:10
Measurement of Liver Stiffness Using Atomic Force Microscopy Coupled with Polarization Microscopy
Published on: July 20, 2022
Liver stiffness measurement by transient elastography as a predictor on posthepatectomy outcomes
Jeff Siu-Wang Wong1, Grace Lai-Hung Wong, Anthony Wing-Hung Chan
1Department of Surgery, The Chinese University of Hong Kong, Hong Kong SAR, China.
Annals of Surgery
|September 25, 2012
Summary
High liver stiffness measurement (LSM) predicts major complications after liver surgery. Preoperative LSM is a valuable tool for assessing patient risk before hepatectomy.
Area of Science:
- Hepatology
- Surgical Oncology
- Medical Diagnostics
Background:
- Liver fibrosis and cirrhosis increase morbidity after hepatectomy.
- Liver stiffness measurement (LSM) via transient elastography accurately detects fibrosis.
- The predictive value of LSM for post-hepatectomy outcomes remains unstudied.
Purpose of the Study:
- To investigate the utility of preoperative liver stiffness measurement (LSM) in predicting major postoperative complications following hepatectomy.
- To compare the predictive performance of LSM with the indocyanine green (ICG) clearance test.
Main Methods:
- Prospective cohort study of 105 patients undergoing hepatectomy.
- Preoperative assessments included liver stiffness measurement (LSM) and indocyanine green (ICG) clearance test.
- Primary outcome was the incidence of major postoperative complications.
Main Results:
- LSM, but not ICG, significantly correlated with major postoperative complications (AUC=0.79, P < 0.001).
- A cutoff LSM of 12.0 kPa predicted complications with 85.7% sensitivity and 71.8% specificity.
- High LSM (>12.0 kPa) was an independent prognostic factor and associated with increased blood loss and transfusion rates.
Conclusions:
- Preoperative high liver stiffness measurement (LSM) predicts worse post-hepatectomy outcomes.
- LSM demonstrates superior predictive accuracy for major complications compared to the ICG test.
- LSM is a valuable preoperative tool for risk stratification in patients undergoing hepatectomy.
Related Concept Videos
01:25Ultrasound II: Endoscopic Ultrasound and FibroScan
Endoscopic Ultrasound (EUS) and FibroScan are valuable diagnostic tools in gastroenterology and hepatology, each with specific applications and techniques.
Endoscopic Ultrasound (EUS):
Endoscopic Ultrasound (EUS):
01:22Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess the...