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An uncommon case of Mycoplasma hominis infection after total disc replacement
Charles-Henri Flouzat-Lachaniette1, Julie Guidon, Jérôme Allain
1Hôpital Henri Mondor, AP-HP - UPEC, Institut du Rachis - Service de Chirurgie Orthopédique et Traumatologique, 51, Avenue du Maréchal de Lattre de Tassigny, 94010, Creteil Cedex, France. charles-henri.flouzat-lachaniette@hmn.aphp.fr
Purpose:
Beside mechanical complications, the majority of adverse events after total disc arthroplasty (TDA) are related to the surgical approach. Septic complications are very uncommon and only one previous case has been published. The objective of this article is to describe the clinical circumstances, treatment, and outcomes of septic complication after TDA at L4-L5, involving an uncommon pathogen (Mycoplasma hominis).
Methods:
A 38-year-old woman underwent a MobiDisc(®) TDA at L4-L5 level for discogenic pain. One month postoperatively, she complained of acute low back and abdominal pain associated with fever (39 °C). C-reactive protein level was elevated (197 mg/L; normal <5 mg/L) and the white blood cell count was normal (7 × 10(9)/L; normal 4-10 × 10(9)/L). A computerized tomography (CT) showed a left psoas-based retroperitoneal abscess. Treatment consisted of open debridement, drainage and empirical antibiotic therapy. Intraoperative cultures yielded M. hominis after 7 days incubation. Antibiotic therapy was adapted and discontinued after 2 months. The patient had failed to mention earlier that she had been suffering from abnormal vaginal discharge for some time and was using an intrauterine contraceptive device.
Results:
At 1.5-year follow-up, review confirmed healing of the infection with biological normalization without residual collection, radiolucent lines or osteolysis around the prosthesis at radiographs, CT and MRI.
Conclusions:
Mycoplasma hominis can be involved as an extragenital pathogen in musculoskeletal infections. Because its culture and identification are difficult, special media and real-time PCR are required in case of postoperative deep wound infection after anterior lumbar spine surgery, especially in the case of previous genitourinary infections, to decrease the delay in diagnosis and treatment.
Insights
Septic complications after total disc arthroplasty (TDA) are rare. This case highlights Mycoplasma hominis as a cause of deep infection, emphasizing the need for specialized diagnostics in suspected cases.
Area of Science:
- Spine surgery
- Infectious diseases
- Medical device infections
Background:
- Adverse events after total disc arthroplasty (TDA) are often linked to surgical approach.
- Septic complications are infrequent, with limited published cases.
- This study focuses on a rare septic complication following TDA at the L4-L5 level.
Observation:
- A 38-year-old woman developed acute low back and abdominal pain with fever one month post-MobiDisc(®) TDA.
- Elevated C-reactive protein and a normal white blood cell count were noted.
- CT revealed a left psoas-based retroperitoneal abscess.
Findings:
- Treatment involved debridement, drainage, and tailored antibiotic therapy.
- Intraoperative cultures identified Mycoplasma hominis after a 7-day incubation period.
- The patient successfully recovered with infection resolution and no prosthesis complications at 1.5-year follow-up.
Implications:
- Mycoplasma hominis can act as an extragenital pathogen in musculoskeletal infections.
- Difficulties in culturing Mycoplasma hominis necessitate specialized media and PCR for timely diagnosis.
- Early diagnosis and treatment are crucial for deep wound infections after anterior lumbar spine surgery, especially with prior genitourinary infections.
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