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Related Experiment Video

Updated: May 18, 2026

Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus
06:55

Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus

Published on: December 5, 2015

Altered maternal left ventricular contractility and function during normal pregnancy.

M E Estensen1, J O Beitnes, G Grindheim

  • 1National Resource Centre for Women's Health, Oslo University Hospital, Rikshospitalet, Oslo, Norway.

Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology
|September 25, 2012
PubMed
Summary
This summary is machine-generated.

Maternal cardiac function changes during pregnancy, with lower left ventricular (LV) contractility and increased LV volume observed. Despite these adaptations, filling pressures remain stable, indicating a significant cardiovascular load.

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Contractility Measurements of Human Uterine Smooth Muscle to Aid Drug Development
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Published on: January 26, 2018

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Last Updated: May 18, 2026

Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus
06:55

Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus

Published on: December 5, 2015

Contractility Measurements of Human Uterine Smooth Muscle to Aid Drug Development
07:56

Contractility Measurements of Human Uterine Smooth Muscle to Aid Drug Development

Published on: January 26, 2018

Area of Science:

  • Cardiovascular Physiology
  • Reproductive Medicine
  • Maternal-Fetal Medicine

Background:

  • Pregnancy significantly alters maternal physiology.
  • Understanding maternal cardiovascular adaptation is crucial for managing pregnancy.

Purpose of the Study:

  • To assess maternal left ventricular (LV) systolic and diastolic function during normal pregnancy.
  • To evaluate LV contractility using non-invasive measures that account for loading conditions.

Main Methods:

  • Echocardiography with tissue Doppler and 2D speckle tracking was used.
  • Subclavian artery pulse trace recordings were obtained.
  • Examinations were conducted at 14-16, 22-24, and 36 weeks' gestation, and 6 months postpartum in 65 women.

Main Results:

  • Cardiac output and LV end-diastolic volume increased during pregnancy.
  • LV ejection fraction, global peak systolic strain, and LV velocity of circumferential fiber shortening (Vcfc) decreased.
  • LV end-systolic wall stress (afterload) increased, indicating reduced LV contractility during pregnancy.

Conclusions:

  • Maternal LV contractility is reduced in normal pregnancy compared to postpartum.
  • Increased LV and left atrial dimensions were observed, with unchanged filling pressures.
  • Pregnancy imposes a substantial load on the maternal cardiovascular system.