Related Experiment Video
Updated: May 18, 2026
Longitudinal In Vivo Imaging and Quantification of Human Pancreatic Islet Grafting and Contributing Host Cells in the Anterior Eye Chamber
Published on: June 11, 2020
Measurement of transplanted pancreatic volume using computed tomography: reliability by intra- and inter-observer
Eva Lundqvist1, Monica Segelsjö, Anna Andersson
1Uppsala University, Department of Radiology, Oncology and Radiation Science, Section of Radiology, Uppsala, Sweden. eva.lundqvist.8954@student.uu.se
Background:
Unlike other solid organ transplants, pancreas allografts can undergo a substantial decrease in baseline volume after transplantation. This phenomenon has not been well characterized, as there are insufficient data on reliable and reproducible volume assessments. We hypothesized that characterization of pancreatic volume by means of computed tomography (CT) could be a useful method for clinical follow-up in pancreas transplant patients.
Purpose:
To evaluate the feasibility and reliability of pancreatic volume assessment using CT scan in transplanted patients.
Material And Methods:
CT examinations were performed on 21 consecutive patients undergoing pancreas transplantation. Volume measurements were carried out by two observers tracing the pancreatic contours in all slices. The observers performed the measurements twice for each patient. Differences in volume measurement were used to evaluate intra- and inter-observer variability.
Results:
The intra-observer variability for the pancreatic volume measurements of Observers 1 and 2 was found to be in almost perfect agreement, with an intraclass correlation coefficient (ICC) of 0.90 (0.77-0.96) and 0.99 (0.98-1.0), respectively. Regarding inter-observer validity, the ICCs for the first and second measurements were 0.90 (range, 0.77-0.96) and 0.95 (range, 0.85-0.98), respectively.
Conclusion:
CT volumetry is a reliable and reproducible method for measurement of transplanted pancreatic volume.
