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Updated: May 18, 2026
11:28
Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus
Published on: October 7, 2011
[Human enterovirus 71 (EV71) resisted type I interferon induced antiviral effect]
Yu Cui1, Juan Song, Qin-Qin Song
1Medical School, Anhui University of Science and Technology, Huainan 232001, China.
Summary
Human enterovirus 71 (EV71) demonstrates resistance to the antiviral effects of type I interferons. This study found EV71 effectively replicates in cells treated with interferon, unlike herpes simplex virus 1.
Area of Science:
- Virology
- Immunology
Context:
- Type I interferons (IFN-α, IFN-β) are crucial for innate antiviral immunity.
- Enterovirus 71 (EV71) is a significant human pathogen.
- Understanding viral resistance mechanisms to interferon is vital for therapeutic development.
Purpose:
- To investigate the resistance of human enterovirus 71 (EV71) to type I interferon-induced antiviral effects.
- To compare the susceptibility of EV71 and herpes simplex virus 1 (HSV-1) to interferon treatment in cell culture.
Summary:
- HeLa cells treated with type I interferons showed inhibited herpes simplex virus 1 (HSV-1) replication, as evidenced by reduced GFP expression and viral DNA.
- In contrast, human enterovirus 71 (EV71) effectively replicated in interferon-treated HeLa cells, indicating resistance to the induced antiviral state.
- This suggests EV71 possesses mechanisms to counteract type I interferon-mediated antiviral responses.
Impact:
- Highlights EV71's ability to evade a key host antiviral defense mechanism.
- Provides insights into viral immune evasion strategies.
- May inform the development of novel antiviral therapies targeting EV71.
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