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Updated: May 18, 2026

Development of an Insert Co-culture System of Two Cellular Types in the Absence of Cell-Cell Contact
Published on: July 17, 2016
Symbiotic two-species contact process
Marcelo Martins de Oliveira1, Renato Vieira Dos Santos, Ronald Dickman
1Departamento de Física e Matemática, Campus Alto Parapeba, Universidade Federal de São João del Rei, 36420-000 Ouro Branco, Minas Gerais, Brazil. mmdeoliveira@ufsj.edu.br
Abstract:
We study a contact process (CP) with two species that interact in a symbiotic manner. In our model, each site of a lattice may be vacant or host individuals of species A and/or B; multiple occupancy by the same species is prohibited. Symbiosis is represented by a reduced death rate μ<1 for individuals at sites with both species present. Otherwise, the dynamics is that of the basic CP, with creation (at vacant neighbor sites) at rate λ and death of (isolated) individuals at a rate of unity. Mean-field theory and Monte Carlo simulation show that the critical creation rate λ(c)(μ) is a decreasing function of μ, even though a single-species population must go extinct for λ<λ(c) (1), the critical point of the basic CP. Extensive simulations yield results for critical behavior that are compatible with the directed percolation (DP) universality class, but with unusually strong corrections to scaling. A field-theoretic argument supports the conclusion of DP critical behavior. We obtain similar results for a CP with creation at second-neighbor sites and enhanced survival at first neighbors in the form of an annihilation rate that decreases with the number of occupied first neighbors.
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