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Related Experiment Videos

Estrogen induces hyperlipidemia in fasted chicks.

B H Cho1, J R Park

  • 1Harlan E. Moore Heart Research Foundation, Champaign, Illinois 61820.

Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
|February 1, 1990
PubMed
Summary

Estrogen treatment causes hyperlipidemia in fed and fasted chicks, with elevated triglycerides. Fasting impacts enzyme activity and hormone-sensitive lipase, indicating complex estrogen effects on lipid metabolism.

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Area of Science:

  • Endocrinology
  • Lipid Metabolism
  • Animal Physiology

Background:

  • Estrogen is known to induce hyperlipidemia.
  • The effect of fasting on estrogen-induced hyperlipidemia is not well understood.

Purpose of the Study:

  • To investigate the impact of fasting on estrogen-induced hyperlipidemia in male growing chicks.
  • To examine the influence of estrogen and fasting on key enzymes involved in lipid metabolism.

Main Methods:

  • Male growing chicks were administered 17 beta-estradiol with or without feed.
  • Plasma and liver lipids were measured.
  • Activities of hepatic malic enzyme, glucose-6-phosphate dehydrogenase, and adipose tissue hormone-sensitive lipase were determined.

Main Results:

Related Experiment Videos

  • Estrogen treatment induced significant hypertriglyceridemia in both fed and fasted chicks.
  • Fasting alone decreased hepatic malic enzyme and glucose-6-phosphate dehydrogenase activities.
  • Estrogen enhanced malic enzyme and glucose-6-phosphate dehydrogenase in fed chicks but had less effect in fasted chicks.
  • Estrogen increased hormone-sensitive lipase activity in fasted chicks but not in fed chicks.
  • Fatty liver was observed in estrogen-treated fed chicks, but not in estrogen-treated fasted chicks.

Conclusions:

  • Hyperlipidemia persists in estrogenized chicks even during fasting.
  • Fasting alters the metabolic response to estrogen, affecting lipid metabolism and enzyme activities.
  • Estrogen's influence on lipid metabolism is complex and modulated by nutritional status.