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Prognosis after percutaneous coronary intervention in patients with psoriasis: a cohort study using Danish nationwide

Ole Ahlehoff1, Jesper Lindhardsen, Gunnar H Gislason

  • 1Department of Cardiology, Copenhagen University Hospital, Gentofte, Hellerup DK-2900, Denmark. olahha01@geh.regionh.dk

BMC Cardiovascular Disorders
|September 26, 2012
PubMed

Insights

Severe psoriasis significantly increases mortality risk after percutaneous coronary revascularization (PCI). Patients with severe psoriasis face higher risks of death and major adverse cardiovascular events post-PCI compared to those without psoriasis.

Area of Science:

  • Cardiology
  • Dermatology
  • Public Health

Background:

  • Psoriasis is linked to higher coronary artery disease risk.
  • The effect of psoriasis on outcomes after percutaneous coronary revascularization (PCI) remains unclear.

Purpose of the Study:

  • To investigate the prognosis of patients with psoriasis undergoing first-time PCI.
  • To assess the association between psoriasis severity and adverse cardiovascular outcomes post-PCI.

Main Methods:

  • A nationwide cohort study of all Danish patients undergoing first-time PCI (2002-2009).
  • Cox regression models were used to analyze risks of all-cause mortality and a composite endpoint (death, myocardial infarction, stroke).
  • Analyses controlled for demographic, socioeconomic, and clinical factors.

Main Results:

  • Severe psoriasis was associated with a significantly increased risk of all-cause mortality (HR 1.67) and the composite endpoint.
  • Mild psoriasis did not show a statistically significant increased risk for either endpoint.
  • Patients with severe psoriasis were less likely to receive guideline-recommended secondary prevention pharmacotherapy.

Conclusions:

  • Severe psoriasis is an independent risk factor for poor prognosis after PCI.
  • This highlights a novel association between severe psoriasis and adverse cardiovascular outcomes.
  • Further research is warranted to understand and mitigate these risks.
Abstract

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