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Related Concept Videos

Telomeres and Telomerase02:41

Telomeres and Telomerase

In eukaryotic DNA replication, a single-stranded DNA fragment remains at the end of a chromosome after the removal of the final primer. This section of DNA cannot be replicated in the same manner as the rest of the strand because there is no 3’ end to which the newly synthesized DNA can attach. This non-replicated fragment results in gradual loss of the chromosomal DNA during each cell duplication. Additionally, it can induce a DNA damage response by enzymes that recognize single-stranded DNA.
Telomeres and Telomerase02:41

Telomeres and Telomerase

In eukaryotic DNA replication, a single-stranded DNA fragment remains at the end of a chromosome after the removal of the final primer. This section of DNA cannot be replicated in the same manner as the rest of the strand because there is no 3’ end to which the newly synthesized DNA can attach. This non-replicated fragment results in gradual loss of the chromosomal DNA during each cell duplication. Additionally, it can induce a DNA damage response by enzymes that recognize single-stranded DNA.
Replication in Eukaryotes02:31

Replication in Eukaryotes

Overview
Replication in Eukaryotes01:29

Replication in Eukaryotes

In eukaryotic cells, DNA replication is highly conserved and tightly regulated. Multiple linear chromosomes must be duplicated with high fidelity before cell division, so there are many proteins that fulfill specialized roles in the replication process. Replication occurs in three phases: initiation, elongation, and termination, and ends with two complete sets of chromosomes in the nucleus.
Many Proteins Orchestrate Replication at the Origin
Eukaryotic replication follows many of the same...
Replicative Cell Senescence02:15

Replicative Cell Senescence

Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...
Replicative Cell Senescence02:15

Replicative Cell Senescence

Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...

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Updated: May 18, 2026

Analyzing Telomeric Protein-DNA Interactions Using Single-Molecule Magnetic Tweezers
11:21

Analyzing Telomeric Protein-DNA Interactions Using Single-Molecule Magnetic Tweezers

Published on: August 30, 2024

Telomeres-structure, function, and regulation.

Weisi Lu1, Yi Zhang, Dan Liu

  • 1State Key Laboratory for Biocontrol, SYSU, Guangzhou, PR China.

Experimental Cell Research
|September 26, 2012
PubMed
Summary
This summary is machine-generated.

Mammalian telomeres, crucial for genome stability, are maintained by the telomerase complex. Dysregulation of telomere maintenance can lead to diseases like cancer and dyskeratosis congenita.

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Modified Terminal Restriction Fragment Analysis for Quantifying Telomere Length Using In-gel Hybridization
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Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence

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Related Experiment Videos

Last Updated: May 18, 2026

Analyzing Telomeric Protein-DNA Interactions Using Single-Molecule Magnetic Tweezers
11:21

Analyzing Telomeric Protein-DNA Interactions Using Single-Molecule Magnetic Tweezers

Published on: August 30, 2024

Modified Terminal Restriction Fragment Analysis for Quantifying Telomere Length Using In-gel Hybridization
11:29

Modified Terminal Restriction Fragment Analysis for Quantifying Telomere Length Using In-gel Hybridization

Published on: July 10, 2017

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence
12:08

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence

Published on: May 22, 2013

Area of Science:

  • Genetics
  • Molecular Biology
  • Cell Biology

Background:

  • Telomeres protect linear chromosome ends, ensuring genome stability and integrity in mammals.
  • Telomere maintenance involves the telomerase holoenzyme and associated proteins forming nucleoprotein structures.
  • The telomerase complex, including telomeric reverse transcriptase (TERT) and telomeric RNA component (TERC), adds repeats to chromosome ends.

Purpose of the Study:

  • To elucidate the mechanisms regulating telomere homeostasis.
  • To identify factors contributing to telomere dysfunction.
  • To explore potential diagnostic and therapeutic strategies for telomere-related diseases.

Main Methods:

  • The study focuses on understanding the molecular mechanisms of telomere maintenance.
  • It involves analyzing the roles of telomerase holoenzyme and telomere-associated proteins.
  • Investigates the consequences of aberrant regulation of these components.

Main Results:

  • Telomere shortening occurs due to the end replication problem without proper maintenance.
  • Aberrant regulation of telomeric proteins and telomerase is linked to diseases.
  • Specific diseases associated with telomere dysfunction include dyskeratosis congenita and various cancers.

Conclusions:

  • Understanding telomere homeostasis mechanisms is vital for disease research.
  • Identifying factors in telomere dysfunction can lead to new diagnostic tools.
  • Insights into telomere biology may facilitate the development of novel therapeutic interventions.