Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
Viral Hepatitis I: Introduction01:28

Viral Hepatitis I: Introduction

Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...
Vaccinations01:51

Vaccinations

Overview

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

ADLM Guidance Document on Incorporating Gender Diversity in Pathology and Laboratory Medicine.

The journal of applied laboratory medicine·2026
Same author

ADLM Guidance Document on Laboratory Testing for Drugs of Misuse to Support the Emergency Department.

The journal of applied laboratory medicine·2026
Same author

Gender-Affirming Feminizing Hormone Therapy.

JAMA internal medicine·2025
Same author

Estradiol Concentrations for Adequate Gender-Affirming Feminizing Therapy: A Systematic Review.

LGBT health·2025
Same author

Laboratory Informatics Approaches to Improving Care for Gender- Diverse Patients.

Clinics in laboratory medicine·2024
Same author

SARS-CoV-2 seropositivity among healthcare professionals in a rural state.

Antimicrobial stewardship & healthcare epidemiology : ASHE·2024

Related Experiment Video

Updated: May 18, 2026

Dried Blood Spots - Preparing and Processing for Use in Immunoassays and in Molecular Techniques
11:28

Dried Blood Spots - Preparing and Processing for Use in Immunoassays and in Molecular Techniques

Published on: March 13, 2015

Positive hepatitis B surface antigen tests due to recent vaccination: a persistent problem.

Carolyn D Rysgaard1, Cory S Morris, Denny Drees

  • 1Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, IA, 52242, USA. mkrasows@healthcare.uiowa.edu.

BMC Clinical Pathology
|September 26, 2012
PubMed
Summary

Transient hepatitis B surface antigen (HBsAg) positivity can occur after HBV vaccination, typically resolving within 14 days. This finding is crucial for accurate HBV infection diagnosis, especially in hemodialysis patients.

More Related Videos

Analysis of HBV-Specific CD4 T-cell Responses and Identification of HLA-DR-Restricted CD4 T-Cell Epitopes Based on a Peptide Matrix
10:37

Analysis of HBV-Specific CD4 T-cell Responses and Identification of HLA-DR-Restricted CD4 T-Cell Epitopes Based on a Peptide Matrix

Published on: October 20, 2021

Related Experiment Videos

Last Updated: May 18, 2026

Dried Blood Spots - Preparing and Processing for Use in Immunoassays and in Molecular Techniques
11:28

Dried Blood Spots - Preparing and Processing for Use in Immunoassays and in Molecular Techniques

Published on: March 13, 2015

Analysis of HBV-Specific CD4 T-cell Responses and Identification of HLA-DR-Restricted CD4 T-Cell Epitopes Based on a Peptide Matrix
10:37

Analysis of HBV-Specific CD4 T-cell Responses and Identification of HLA-DR-Restricted CD4 T-Cell Epitopes Based on a Peptide Matrix

Published on: October 20, 2021

Area of Science:

  • Hepatology
  • Immunology
  • Vaccinology

Background:

  • Hepatitis B virus (HBV) infection poses significant health risks, including cirrhosis and liver cancer.
  • Hepatitis B surface antigen (HBsAg) assays are primary tools for HBV detection.
  • The transient HBsAg positivity post-HBV vaccination requires clarification.

Purpose of the Study:

  • To determine the frequency and duration of transient HBsAg positivity after HBV vaccination.
  • To investigate the impact of vaccination on HBsAg test results.

Main Methods:

  • Retrospective chart review of HBsAg tests and HBV vaccination records.
  • Analysis of electronic medical records from an academic tertiary care center.
  • Identification of patients vaccinated within 180 days prior to HBsAg testing.

Main Results:

  • Transient HBsAg positivity was observed in 11 out of 34 patients vaccinated within 14 days.
  • Positivity peaked 2-3 days post-vaccination and resolved within 14 days.
  • Weakly positive (grayzone) HBsAg results were rarely due to true HBV infection (4/43).

Conclusions:

  • Transient HBsAg positivity post-HBV vaccination is confirmed and typically lasts less than 14 days.
  • Confirmatory testing is essential for accurate HBV infection diagnosis due to false positives.
  • Hemodialysis patients are most commonly affected by vaccination-induced HBsAg positivity.