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Updated: May 18, 2026

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment

Published on: December 3, 2020

Physiologically based pharmacokinetic/toxicokinetic modeling.

Jerry L Campbell¹, Rebecca A Clewell, P Robinan Gentry

¹The Hamner Institutes for Health Sciences, Research Triangle Park, NC, USA. jcampbell@thehamner.org

Methods in Molecular Biology (Clifton, N.J.)

|September 26, 2012

Summary

Physiologically based pharmacokinetic (PBPK) models use organism physiology for toxicological risk assessment. This approach links chemical effects to target tissue exposure, improving safety evaluations using styrene as an example.

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Area of Science:

Pharmacokinetics and Toxicology
Computational Biology
Risk Assessment

Background:

Conventional pharmacokinetic models do not fully capture organism physiology.
Linking toxic effects to target tissue concentration is crucial for risk assessment.
Physiologically based pharmacokinetic (PBPK) models offer a more physiologically relevant approach.

Purpose of the Study:

To explain Physiologically Based Pharmacokinetic (PBPK) modeling.
To demonstrate the utility of PBPK models in chemical safety assessment.
To outline the procedures for developing and implementing PBPK models using styrene as an example.

Main Methods:

Development of a PBPK model incorporating physiological parameters.
Utilizing the PBPK model to simulate chemical concentration-time courses in tissues.
Applying the PBPK model for chemical safety and risk assessment.

Main Results:

PBPK models provide a direct link between administered dose and target tissue exposure.
The styrene PBPK model exemplifies the practical application of PBPK in safety assessment.
PBPK modeling enhances the understanding of chemical disposition and toxicodynamics.

Conclusions:

PBPK models are valuable tools for toxicology and risk assessment.
Relating toxic effects to target tissue exposure improves the accuracy of safety evaluations.
The presented methodology facilitates the development and implementation of PBPK models for various chemicals.