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Updated: May 18, 2026

Continuous Video Electroencephalogram during Hypoxia-Ischemia in Neonatal Mice
Published on: June 11, 2020
Treatment of refractory neonatal seizures with topiramate
Rudimar Riesgo1, Maria Isabel Winckler, Lygia Ohlweiler
1Child Neurology Unit, Department of Pediatrics, UFRGS, Porto Alegre, Rio Grande do Sul, Brazil. rriesgo@hcpa.ufrgs.br
Objective:
The objective of this study is to describe the usefulness of topiramate in refractory neonatal seizures.
Results:
We reported the clinical off-label use of topiramate in three cases of refractory neonatal seizures of unclear origin with no response to conventional antiepileptic drugs. In all cases, the seizures were completely controlled with adding topiramate. All patients became seizure free during hospitalization and were followed by approximately 1 year after hospital discharge, with monotherapy with topiramate.
Comments:
The clinical off-label use of topiramate in neonatal seizures is still incipient. When searching publications in this matter, only one report was identified. Because of its efficacy for both seizures and neuroprotection, topiramate could be a useful choice in refractory neonatal seizures.
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