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Related Concept Videos

Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...
Regulation of Expression at Multiple Steps01:23

Regulation of Expression at Multiple Steps

The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the addition of a...
Regulation of Expression Occurs at Multiple Steps02:24

Regulation of Expression Occurs at Multiple Steps

Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
Regulation of Expression Occurs at Multiple Steps02:24

Regulation of Expression Occurs at Multiple Steps

Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...

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Related Experiment Video

Updated: May 18, 2026

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
14:56

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies

Published on: May 6, 2022

Expression profiling based on coexpressed modules in obese prepubertal children.

J F Zhang1, G Y Yao, Y H Wu

  • 1Department of Child Health Care, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai, China.

Genetics and Molecular Research : GMR
|September 26, 2012
PubMed
Summary
This summary is machine-generated.

This study identifies novel genes and molecular mechanisms linked to metabolic syndrome in obesity using coexpression networks. Findings highlight pathways in xenobiotic metabolism and cell cycle, suggesting new research directions for obesity-related disorders.

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Assessment of Child Anthropometry in a Large Epidemiologic Study
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Assessment of Child Anthropometry in a Large Epidemiologic Study

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Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
14:56

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies

Published on: May 6, 2022

Assessment of Child Anthropometry in a Large Epidemiologic Study
09:36

Assessment of Child Anthropometry in a Large Epidemiologic Study

Published on: February 2, 2017

Area of Science:

  • Genomics
  • Molecular Biology
  • Metabolic Research

Background:

  • Obesity is linked to metabolic syndrome, a cluster of clinical and metabolic abnormalities.
  • Understanding the molecular underpinnings of obesity and metabolic syndrome is crucial for developing effective interventions.

Purpose of the Study:

  • To identify genes associated with metabolic syndrome in obese patients.
  • To elucidate the molecular mechanisms driving these abnormalities through gene expression analysis.

Main Methods:

  • Construction of a coexpression network to analyze gene expression profiles.
  • Development of a similarity matrix and expression modules.
  • Domain and pathway enrichment analysis to identify key biological processes.

Main Results:

  • Module 1 genes are implicated in xenobiotic metabolism (cytochrome P450), aldosterone-regulated sodium reabsorption, and focal adhesion.
  • Module 3 genes are associated with cell cycle and DNA replication pathways.
  • Identification of understudied genes and pathways requiring further investigation.

Conclusions:

  • Gene expression profiling reveals distinct molecular pathways in obese patients with metabolic syndrome.
  • Specific gene modules suggest novel roles in metabolic dysregulation and cellular processes.
  • Further research is needed to validate the identified genes and pathways for therapeutic targeting.