Related Experiment Video
Updated: May 18, 2026

The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis
Published on: August 11, 2008
Drug-susceptibility pattern of mycobacterium tuberculosis among pulmonary tuberculosis patients in riyadh, saudi
1Field Epidemiology Training Program, Ministry of Health, Riyadh, Saudi Arabia.
Objective:
To identify the pattern of drug-susceptibility of newly diagnosed pulmonary tuberculosis patients in Riyadh, we conducted a study on all Mycobacterium tuberculosis positive-culture patients admitted to Sahari Chest Hospital from January 1994 to April 1995.
Methods:
Demographic data, antituberculous therapy and drug-susceptibility testing results of each patient were reviewed from patients' hospital records. The samples were cultured on Lowenstein-Jensen media and drug susceptibility was tested by Bactec 12B (Middlebrook 7H12) media against selected antituberculous drugs
Results:
Drug susceptibility was performed on 362 (91%) of the sputum positive-cultures. The overall initial resistance rate (1 or more drugs) was 12.4%. Initial. resistance was more common with a single drug (9.4%), followed by two drugs (2.3%) and then three drugs (0.3%). Resistance to isoniazid was most common (10.4%), followed by streptomycin (2.7%), rifampicin (1.9%) and ethambutol (0.6%). Single isoniazid resistance was 60%, followed by two drugs: streptomycin and isoniazid (13.3%).
Conclusion And Recommendations:
Resistance to multiple drugs is not yet a significant problem in Riyadh. A continuous monitoring of drug resistance is important for planning and assessing the national TB control program. Timely and complete reporting is essential to identify the problem as and when it begins.
Related Concept Videos
Pulmonary Tuberculosis V
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
Pulmonary Tuberculosis IV
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Pulmonary Tuberculosis I
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Pulmonary Tuberculosis III
The first classification is based on the development of the disease, and it includes the following categories:
Clinical Significance of Antibiotic Resistance
Pulmonary Tuberculosis II
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...