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Related Experiment Video

Updated: May 18, 2026

A Rat Model of Compound Acne

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Published on: November 1, 2024

No link between rosacea and Propionibacterium acnes.

Anika C Jahns¹, Bertil Lundskog, Ida Dahlberg

¹Department of Medical Biosciences/Pathology, Umeå University, Umeå, Sweden.

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica

|September 27, 2012

Summary

Propionibacterium acnes (P. acnes) was investigated in rosacea patients. This study found P. acnes is unlikely to be a major factor in rosacea development.

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Area of Science:

Dermatology
Microbiology
Pathogenesis

Background:

Rosacea is a prevalent adult facial skin condition.
Inflammation is implicated in rosacea pathogenesis, but triggers remain unclear.
Previous research suggested microbial involvement in rosacea development.

Purpose of the Study:

To investigate the presence and localization of Propionibacterium acnes (P. acnes) in facial skin biopsies of rosacea patients.
To determine if P. acnes plays a significant role in the pathogenesis of rosacea.

Main Methods:

Facial skin biopsies were collected from 82 rosacea patients and 25 controls.
Biopsies were stained using a P. acnes-specific monoclonal antibody (QUBPa3).
Presence of P. acnes was visualized in skin compartments.

Main Results:

P. acnes was detected in 8.5% (7 out of 82) of rosacea patients.
In positive cases, P. acnes appeared as either a biofilm (57%) or a microcolony (43%).
No P. acnes was detected in control subjects (data not shown, implied).

Conclusions:

Propionibacterium acnes is infrequently found in the skin of rosacea patients.
The findings suggest P. acnes does not play a major role in the pathogenesis of rosacea.
Further research may be needed to identify other initiating factors in rosacea.