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Targeting the ATF4 pathway in cancer therapy

Dean C Singleton1, Adrian L Harris

  • 1University of Oxford, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Department of Oncology, Oxford OX3 9DS, UK.

Expert Opinion on Therapeutic Targets
|September 27, 2012
PubMed
Summary

Activating transcription factor 4 (ATF4) is crucial for cancer cell survival under stress. Targeting ATF4 translation or its downstream pathways offers promising therapeutic strategies for cancer treatment resistance.

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