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Updated: May 18, 2026

A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma

A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma

Published on: January 5, 2017

Perineural tumor spread - Interconnection between spinal and cranial nerves.

Duško Kozić¹, Vesna Njagulj, Jelena Popadić Gaćeša

¹University of Novi Sad, School of Medicine, Institute of Oncology, Diagnostic Imaging Center, Institutski put 4, 21204 Sremska Kamenica, Serbia. dusko.b.kozic@gmail.com

Journal of the Neurological Sciences

|September 27, 2012

Summary

Secondary involvement of the cervical plexus by head and neck cancer is rare. This case highlights neoplastic infiltration of the C2 root and associated nerves, offering new insights into cancer spread.

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Area of Science:

Neurology
Oncology
Radiology

Background:

Secondary involvement of the cervical plexus by malignancies is exceptionally rare.
Head and neck cancers can present with complex metastatic patterns.

Observation:

A 57-year-old patient with a history of tongue squamous cell carcinoma presented with persistent right ear pain.
Magnetic Resonance (MR) imaging of the neck revealed diffuse neoplastic infiltration of the right C2 root.

Findings:

The MR examination demonstrated perineural tumor spread.
Distal involvement of the great auricular nerve and vagus nerve was evident.
This case represents the first documented instance of cervical plexus involvement in head and neck cancer, detailing its interconnection with cranial nerves via the great auricular nerve.

Implications:

This finding expands the understanding of cancer spread pathways in head and neck malignancies.
Highlights the importance of considering perineural spread in patients with unexplained head and neck pain.
Suggests the need for detailed imaging protocols to evaluate cervical plexus involvement in relevant oncological cases.