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Serum high-density lipoprotein cholesterol and progression to arterial stiffness in middle-aged and elderly Chinese

W W Zhao1, Y H Yang, B Lu

  • 1Department of Endocrinology and Diabetology, Huashan Hospital, Shanghai Medical College, Fudan University, No.12, Wulumuqi Middle Road, Shanghai 200040, China.

Nutrition, Metabolism, and Cardiovascular Diseases : NMCD
|September 27, 2012
PubMed

Insights

Low high-density lipoprotein cholesterol (HDL-c) is linked to arterial stiffness in older Chinese adults. Higher HDL-c levels were associated with a reduced risk of developing arterial stiffness, suggesting a protective role.

Area of Science:

  • Cardiovascular Health
  • Biomarkers
  • Geriatric Medicine

Background:

  • Low high-density lipoprotein cholesterol (HDL-c) is a known risk factor for cardiovascular disease.
  • Brachial-ankle pulse wave velocity (baPWV) measures arterial stiffness, a predictor of cardiovascular disease.
  • Investigating the relationship between HDL-c and arterial stiffness is crucial for cardiovascular risk assessment.

Purpose of the Study:

  • To examine the association between HDL-c levels and baPWV in middle-aged and elderly Chinese individuals.
  • To determine if HDL-c independently predicts arterial stiffness in this population.
  • To explore the potential of HDL-c as a therapeutic target for arterial stiffness.

Main Methods:

  • Cross-sectional study involving 1133 Chinese participants aged 50-90 years.
  • Measurement of brachial-ankle pulse wave velocity (baPWV) and major cardiovascular risk factors.
  • Statistical analysis including correlation, multivariate linear regression, and odds ratio calculation.

Main Results:

  • Serum HDL-c showed a significant negative correlation with baPWV (r = -0.143, P < 0.001).
  • HDL-c was independently associated with baPWV after adjusting for age, gender, and other risk factors.
  • Participants with the highest HDL-c quartile had a significantly lower odds of high arterial stiffness (OR = 0.442).

Conclusions:

  • HDL-c exerts an independent protective effect on arterial stiffness in middle-aged and elderly Chinese.
  • Monitoring HDL-c levels is important for individuals at high risk for arterial stiffness.
  • Increasing HDL-c may be a viable strategy for preventing arterial dysfunction and related diseases.
Abstract

Keywords:
Arterial stiffnessBrachial-ankle pulse wave velocity (baPWV)High-density lipoprotein cholesterol (HDL-c)

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