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Updated: May 18, 2026

Direct Mouse Trauma/Burn Model of Heterotopic Ossification
Published on: August 6, 2015
Heterotopic ossification in orthopaedic trauma
Aaron Nauth1, Erica Giles, Benjamin K Potter
1Department of Surgery, Division of Orthopaedics, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
Abstract:
Heterotopic ossification (HO) can be defined as the pathologic formation of bone in extraskeletal tissues. There has been a substantial amount of recent research on the pathophysiology, prophylaxis, and treatment of HO and traumatic conditions associated with the development of HO. This research has advanced our understanding of this disease and helped to clarify evidence-based approaches to both the prophylaxis and treatment of HO. This article reviews the literature on these topics with a focus on their application in orthopaedic trauma.
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