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Updated: May 18, 2026
03:36
Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
Esophageal carcinosarcoma: a unique entity with better prognosis
Liang Wang1, Yongbin Lin, Hao Long
1Department of Hematologic Oncology, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, People's Republic of China.
Annals of Surgical Oncology
|September 27, 2012
Summary
The neutrophil to lymphocyte ratio (NLR) is a key indicator of poor prognosis in esophageal carcinosarcoma patients. Elevated NLR independently predicts worse survival and recurrence after curative resection.
Area of Science:
- Oncology
- Surgical Pathology
- Biomarkers
Background:
- Esophageal carcinosarcoma is a rare malignancy.
- Identifying patients with poor prognosis is crucial for effective treatment and improved survival.
Purpose of the Study:
- To analyze clinical characteristics, pathology, treatments, and outcomes of esophageal carcinosarcoma.
- To investigate the prognostic value of the neutrophil-to-lymphocyte ratio (NLR).
Main Methods:
- Retrospective analysis of 33 esophageal carcinosarcoma patients.
- Evaluation of clinical, pathological, and treatment data.
- Correlation of preoperative neutrophil-to-lymphocyte ratio (NLR) with overall survival (OS) and relapse-free survival (RFS).
Main Results:
- Squamous cell carcinoma was the predominant carcinomatous element.
- Elevated NLR (≥5) was observed in 8 patients.
- Higher NLR was significantly associated with poorer OS and RFS in patients undergoing curative resection.
- Multivariate analysis confirmed NLR as an independent prognostic factor for both OS and RFS (P=0.001).
Conclusions:
- Baseline NLR is an independent prognostic factor for curatively resected esophageal carcinosarcoma.
- NLR can aid in identifying patients with poor prognosis, guiding treatment strategies.
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