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Related Concept Videos

Hypersensitivities01:30

Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Hypersensitivity Reactions: Immune-Complex Reactions01:19

Hypersensitivity Reactions: Immune-Complex Reactions

Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum sickness, a systemic...
Hypersensitivity Reactions: Delayed Hypersensitivity Reactions01:29

Hypersensitivity Reactions: Delayed Hypersensitivity Reactions

Delayed-Type Hypersensitivity (DTH), or Type IV hypersensitivity, is a cell-mediated immune response. It occurs when T cells, rather than antibodies, mediate a reaction to specific antigens. It is characterized by a delayed onset (1-2 days) and involves the recruitment of macrophages to the inflammation site.The initiation of a DTH response begins with the sensitization of T cells. During this phase, which lasts at least 1-2 weeks, antigen-specific T cells are activated, clonally expanded, and...
Allergic Reactions02:06

Allergic Reactions

Overview
Other Disorders of Digestive System01:30

Other Disorders of Digestive System

The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...

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Related Experiment Video

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Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

Cutaneous hypersensitivity to gluten.

Antonella Tammaro1, Alessandra Narcisi, Gabriella De Marco

  • 1U.O.C. Dermatology, NESMOS Department, Faculty of Medicine and Psychology, Sapienza University, Rome, Italy.

Dermatitis : Contact, Atopic, Occupational, Drug
|September 27, 2012
PubMed
Summary
This summary is machine-generated.

Celiac disease patients with skin issues improved by avoiding gluten in personal care products and foods. Strict avoidance of wheat and durum wheat prevented dermatitis relapses over six months.

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Area of Science:

  • Dermatology
  • Gastroenterology
  • Immunology

Background:

  • Celiac disease is an autoimmune disorder triggered by gluten ingestion.
  • Dermatologic manifestations, such as eczematous lesions, can occur in celiac disease patients.
  • External gluten exposure through personal care products may exacerbate skin conditions.

Purpose of the Study:

  • To investigate the link between external gluten exposure and eczematous dermatitis in celiac disease patients.
  • To evaluate the efficacy of gluten avoidance in personal care products and food handling for managing skin lesions.

Main Methods:

  • Study included 14 female celiac disease patients with skin lesions.
  • Patch testing with wheat and durum wheat was performed.
  • Patients implemented gluten-free personal care products and modified food handling practices.

Main Results:

  • Five patients showed positive patch test reactions to wheat and durum wheat.
  • Implementing gluten-free products and protective measures led to significant improvement in skin lesions.
  • No dermatitis relapses were observed during the 6-month follow-up period.

Conclusions:

  • External gluten exposure can trigger or worsen eczematous dermatitis in susceptible celiac disease patients.
  • A gluten-free diet and careful avoidance of external gluten sources are crucial for managing dermatologic symptoms.
  • Personal care product formulation and food handling require consideration for celiac disease patients with skin involvement.