Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Aquaporin water channels: New perspectives on the potential role in inflammation.

Advances in protein chemistry and structural biology·2019

Same author

Angiogenesis in Pancreatic Cancer: Pre-Clinical and Clinical Studies.

Cancers·2019

Same author

Inflammatory cells infiltrate and angiogenesis in locally advanced and metastatic cholangiocarcinoma.

European journal of clinical investigation·2019

Same author

Microvascular density, macrophages, and mast cells in human clear cell renal carcinoma with and without bevacizumab treatment.

Urologic oncology·2019

Same author

Immunophenotypic characterization of telocyte-like cells in pterygium.

Molecular vision·2019

Same author

α-Methyl-prednisolone normalizes the PKC mediated brain angiogenesis in dystrophic mdx mice.

Brain research bulletin·2019

Same journal

Endothelial Notch1 drives multicellular remodelling during hyaloid vessel regression.

Angiogenesis·2026

Same journal

Endothelial protein C receptor and the endothelial progenitor paradigm: towards a functional definition at last.

Angiogenesis·2026

Same journal

Tumour endothelial cell reprogramming orchestrates angiocrine signalling to drive chemoresistance in breast cancer.

Angiogenesis·2026

Same journal

A possible microvascular vulnerability in carotid artery dissection: insights from nailfold capillaroscopy.

Angiogenesis·2026

Same journal

miR-150 controls developmental angiogenesis via ribosome biogenesis-dependent regulation of Notch signaling.

Angiogenesis·2026

Same journal

MCC links Wnt/PCP signaling to endothelial polarity and vascular remodeling.

Angiogenesis·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jan 10, 2026

Micropatterning and Assembly of 3D Microvessels

Micropatterning and Assembly of 3D Microvessels

Published on: September 9, 2016

Endothelialization approaches for viable engineered tissues.

Silvia Baiguera¹, Domenico Ribatti

¹BIOAIRLab, European Center for Thoracic Surgery, University Hospital Careggi, Florence, Italy. sbaiguer@libero.it

|September 27, 2012

Summary

This summary is machine-generated.

Creating functional blood vessels is key for 3D engineered tissues. This review explores cell-based strategies for vascularizing tissue-engineered constructs, focusing on endothelial cell behavior and in vivo applications.

More Related Videos

Tissue Engineering by Intrinsic Vascularization in an In Vivo Tissue Engineering Chamber

Tissue Engineering by Intrinsic Vascularization in an In Vivo Tissue Engineering Chamber

Published on: May 30, 2016

Generation and Grafting of Tissue-engineered Vessels in a Mouse Model

Generation and Grafting of Tissue-engineered Vessels in a Mouse Model

Published on: March 18, 2015

Related Experiment Videos

Last Updated: Jan 10, 2026

Micropatterning and Assembly of 3D Microvessels

Micropatterning and Assembly of 3D Microvessels

Published on: September 9, 2016

Tissue Engineering by Intrinsic Vascularization in an In Vivo Tissue Engineering Chamber

Tissue Engineering by Intrinsic Vascularization in an In Vivo Tissue Engineering Chamber

Published on: May 30, 2016

Generation and Grafting of Tissue-engineered Vessels in a Mouse Model

Generation and Grafting of Tissue-engineered Vessels in a Mouse Model

Published on: March 18, 2015

Area of Science:

Biomedical Engineering
Regenerative Medicine
Tissue Engineering

Background:

Thick, 3D engineered tissues require a functional vascular system for survival and integration.
Endothelial cells are crucial for neovascularization and blood vessel function.
Environmental factors significantly impact endothelial cell behavior and vessel formation.

Purpose of the Study:

To review current techniques for vascularizing tissue-engineered constructs.
To highlight recent advancements in cell-based vascularization strategies.
To discuss the in vivo applications of engineered vascular networks.

Main Methods:

Overview of existing vascularization strategies (growth factors, scaffolds, prevascularization, cell-based).
Focus on endothelial cell biology and its role in angiogenesis.
Analysis of environmental influences on endothelial cells (origin, co-culture, biomaterials, hemodynamics).

Main Results:

Various strategies exist for tissue construct vascularization, each with pros and cons.
Cell-based strategies show promise for creating functional vascular networks.
Environmental cues critically modulate endothelial cell function and angiogenic potential.

Conclusions:

Effective vascularization remains a significant challenge in tissue engineering.
Cell-based approaches, considering environmental influences, are advancing the field.
Further research into in vivo applications is essential for clinical translation.