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Related Concept Videos

Sleep Apnea01:21

Sleep Apnea

Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

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Chronic Inflammation
Insufficient Sleep and Sleep Deprivation01:13

Insufficient Sleep and Sleep Deprivation

Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
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Other Pulmonary Disorders01:17

Other Pulmonary Disorders

Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.
Chronic Obstructive Pulmonary Disease II: Emphysema01:23

Chronic Obstructive Pulmonary Disease II: Emphysema

Emphysema, a major phenotype of chronic obstructive pulmonary disease (COPD), is characterized by irreversible destruction of alveolar walls and permanent enlargement of distal airspaces. Unlike chronic bronchitis, which primarily affects the airways, emphysema predominantly involves the lung parenchyma, where structural damage leads to airflow limitation.PathophysiologyIt most commonly results from prolonged exposure to cigarette smoke and other toxic gases, particularly cigarette smoke.
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...

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Related Experiment Video

Updated: May 18, 2026

Induction and Analysis of Oxidative Stress in Sleeping Beauty Transposon-Transfected Human Retinal Pigment Epithelial Cells
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[Obstructive sleep apnoea and oxidative stress].

M Westhoff1, P Litterst

  • 1Klinik für Pneumologie, Intensiv- und Schlafmedizin, Lungenklinik Hemer. westhoff@lkhemer.de

Pneumologie (Stuttgart, Germany)
|September 27, 2012
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Continuous positive airway pressure (CPAP) therapy for obstructive sleep apnoea (OSA) significantly reduces hydrogen peroxide (H2O2) in exhaled breath condensate (EBC) after six weeks. This indicates reduced airway inflammation and oxidative stress in OSA patients.

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Area of Science:

  • Respiratory Medicine
  • Biochemistry
  • Sleep Medicine

Context:

  • Obstructive sleep apnoea (OSA) is linked to increased systemic and local oxidative stress and inflammation.
  • Exhaled breath condensate (EBC) offers a non-invasive method to assess metabolites and inflammation markers.
  • Severe OSA (AHI ≥ 30/h) warrants investigation into therapeutic effects on oxidative stress markers.

Purpose:

  • To investigate if CPAP therapy normalizes Apnea-Hypopnea Index (AHI) and reduces H2O2 concentrations in EBC.
  • To assess changes in EBC H2O2 levels after short-term and long-term CPAP treatment in severe OSA patients.

Summary:

  • A study analyzed EBC H2O2 in 23 severe OSA patients (AHI ≥ 30/h) before and after CPAP therapy.
  • While the first night of CPAP reduced AHI, EBC H2O2 levels remained unchanged.
  • After six weeks of CPAP, with normalized AHI (≤ 10/h), EBC H2O2 significantly decreased from 450 ± 163 to 294 ± 110 nmol/L.

Impact:

  • CPAP therapy effectively reduces local airway inflammation and oxidative stress in OSA patients.
  • The findings suggest CPAP therapy has a positive systemic effect on oxidative stress in OSA.
  • Further research is needed to explore the influence of smoking status on these outcomes.