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The role of annexin A3 playing in cancers

Na Wu1, Shuqing Liu, Chunmei Guo

  • 1Department of Biotechnology, Dalian Medical University, Dalian, 116044, China.

Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
|September 27, 2012
PubMed

Insights

Annexin A3 (Anxa3) plays a dual role in cancer, acting as a tumor suppressor or promoter. Its expression levels correlate with tumor development, metastasis, and drug resistance across various cancers.

Area of Science:

  • Molecular Biology
  • Oncology
  • Biochemistry

Background:

  • Annexin family proteins are Ca(2+)-regulated phospholipid- and membrane-binding proteins.
  • Annexin A3 (Anxa3) is increasingly recognized for its involvement in cancer progression.
  • Anxa3's function can vary, acting as either a tumor suppressor or promoter depending on cancer type.

Purpose of the Study:

  • To summarize current research on the role of Annexin A3 in cancer.
  • To elucidate the dual function of Anxa3 in tumor development, metastasis, and drug resistance.
  • To highlight Anxa3 as a potential biomarker and therapeutic target in oncology.

Main Methods:

  • Review of accumulated research evidence on Annexin A3.
  • Analysis of Anxa3 expression correlations with various cancer types.
  • Synthesis of data on Anxa3's impact on tumor progression and drug resistance.

Main Results:

  • Anxa3 up-regulation is linked to enhanced drug resistance in ovarian cancer.
  • Anxa3 promotes colorectal and pancreatic adenocarcinoma development.
  • Anxa3 facilitates lung and hepatocarcinoma metastasis.
  • Decreased Anxa3 expression is negatively correlated with prostatic and renal carcinoma development.

Conclusions:

  • Annexin A3 exhibits context-dependent roles in cancer, acting as either a suppressor or promoter.
  • Anxa3 expression levels serve as potential biomarkers for tumor development, invasion, metastasis, and patient prognosis.
  • Anxa3 represents a promising target for novel cancer therapeutic interventions.

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