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Diagnostic exercise: Submucosal gastric masses in a cat
K Brosinski1, W A Burkhardt, C Venzin
1Institute of Veterinary Pathology, Vetsuisse Faculty, University of Zurich, Winterthurerstr 268, CH-8057 Zurich, Switzerland.
Veterinary Pathology
|September 27, 2012
Summary
A cat
Area of Science:
- Veterinary Pathology
- Feline Oncology
- Gastrointestinal Disease
Background:
- Chronic vomiting in cats can indicate various gastrointestinal pathologies.
- Submucosal gastric masses require thorough histopathological evaluation for accurate diagnosis.
Observation:
- A 14-year-old cat presented with chronic vomiting and two submucosal gastric masses.
- Histology revealed medium-sized round cells with eosinophils and fibroblastic stroma.
- Marked epitheliotropism was noted in the overlying mucosa.
Findings:
- Immunohistochemistry confirmed neoplastic cells were positive for CD3 (T-cell marker) and negative for CD79a (B-cell marker) and CD117 (mast cell marker).
- Special stains (Giemsa, SNOBA) were negative.
- Diagnosis was T-cell lymphoma with reactive fibroplasia, excluding mast cell tumor and feline gastrointestinal eosinophilic sclerosing fibroplasia.
Implications:
- This case highlights the importance of immunohistochemistry in differentiating feline gastric tumors.
- Accurate diagnosis of T-cell lymphoma is crucial for appropriate treatment and prognosis in cats.
- Understanding reactive fibroplasia associated with lymphoma aids in surgical planning and management.
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