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[Transcriptional regulation of RAAS genes--in vivo analysis by artificial chromosome transgenic mouse]

Keiji Tanimoto1, Akiyoshi Fukamizu

  • 1Faculty of Life and Environmental Sciences, University of Tsukuba.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|September 28, 2012
PubMed
Abstract

No abstract available in PubMed .

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The Ras-gene-encoded proteins are regulators of signaling pathways controlling cell proliferation, differentiation, or cell survival. The Ras-gene family in humans constitutes three primary members—the HRas, NRas, and KRas. These genes code for four functionally distinct yet closely related proteins—the HRas, NRas, KRas4A, and KRas4B. The involvement of mutant Ras genes in human cancer was first discovered in 1982 and is among the most common causes of human tumorigenesis.
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