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Transducer Mechanism: Nuclear Receptors

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The Two-State Receptor Model

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Related Experiment Video

Updated: May 18, 2026

Induction of Atherosclerotic Plaques Through Activation of Mineralocorticoid Receptors in Apolipoprotein E-deficient Mice

Induction of Atherosclerotic Plaques Through Activation of Mineralocorticoid Receptors in Apolipoprotein E-deficient Mice

Published on: September 26, 2018

[Mineralocorticoid receptor: an update].

¹Division of Chronic Kidney Disease, Department of Nephrology and Endocrinology, University of Tokyo Graduate School of Medicine.

Nihon Rinsho. Japanese Journal of Clinical Medicine

|September 28, 2012

Summary

The aldosterone-mineralocorticoid receptor (MR) system plays a key role in target organ damage, beyond its known function in blood pressure regulation. Research highlights MR overactivation in chronic kidney disease and cardiac injury, with new insights into its ligand-independent activation.

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Implementing Patch Clamp and Live Fluorescence Microscopy to Monitor Functional Properties of Freshly Isolated PKD Epithelium

Implementing Patch Clamp and Live Fluorescence Microscopy to Monitor Functional Properties of Freshly Isolated PKD Epithelium

Published on: September 1, 2015

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Last Updated: May 18, 2026

Induction of Atherosclerotic Plaques Through Activation of Mineralocorticoid Receptors in Apolipoprotein E-deficient Mice

Induction of Atherosclerotic Plaques Through Activation of Mineralocorticoid Receptors in Apolipoprotein E-deficient Mice

Published on: September 26, 2018

Implementing Patch Clamp and Live Fluorescence Microscopy to Monitor Functional Properties of Freshly Isolated PKD Epithelium

Implementing Patch Clamp and Live Fluorescence Microscopy to Monitor Functional Properties of Freshly Isolated PKD Epithelium

Published on: September 1, 2015

Area of Science:

Endocrinology
Nephrology
Cardiology

Context:

The aldosterone-mineralocorticoid receptor (MR) system is traditionally recognized for its role in regulating body fluid and blood pressure.
A paradigm shift occurred with the RALES trial, highlighting the MR system's involvement in target organ damage.
Recent research, including studies with genetically-engineered mice, has elucidated novel aspects of MR action in cardiac injury pathophysiology.

Purpose:

To review recent advancements in mineralocorticoid receptor (MR) research.
To discuss the anti-proteinuric effects of MR antagonists.
To examine the role of MR overactivation in chronic kidney disease progression and ligand-independent MR activation.

Summary:

The aldosterone-mineralocorticoid receptor (MR) system, beyond its homeostatic functions, is implicated in target organ damage.
Studies reveal MR's role in cardiac injury and chronic kidney disease progression.
Novel mechanisms, including ligand-independent MR activation, are being explored.

Impact:

Provides a comprehensive overview of current mineralocorticoid receptor (MR) research.
Highlights the therapeutic potential of MR antagonists in kidney and heart disease.
Advances understanding of MR's complex role in various disease states.