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Updated: May 18, 2026
12:03
Receptor Autoradiography Protocol for the Localized Visualization of Angiotensin II Receptors
Published on: June 7, 2016
[Cancer and renin-angiotensin system]
Hiroji Uemura1, Yoshinobu Kubota
1Department of Urology, Yokohama City University Graduate School of Medicine.
Nihon Rinsho. Japanese Journal of Clinical Medicine
|September 28, 2012
Summary
The renin-angiotensin system (RAS) is involved in cardiovascular regulation and cancer development. Angiotensin receptor blockers show anti-tumor effects by inhibiting angiogenesis in various cancers.
Area of Science:
- Cardiovascular Science
- Oncology
- Molecular Biology
Context:
- The renin-angiotensin system (RAS) is crucial for cardiovascular regulation.
- Emerging evidence links RAS to cancer development and invasion.
- Specific RAS components and genetic variations may influence malignancy.
Purpose:
- To provide an overview of the renin-angiotensin system's role in cancer.
- To highlight recent findings on RAS and anti-cancer mechanisms.
- To discuss the implications of RAS in various cancer types.
Summary:
- The renin-angiotensin system (RAS) is implicated in the pathogenesis of several cancers.
- AT1 receptor blockers demonstrate anti-tumor properties by inhibiting angiogenesis.
- Angiotensin peptides and ACE gene polymorphisms are associated with cancer risk and malignancy.
Impact:
- This review offers insights into the cutting-edge research of RAS in oncology.
- Understanding RAS in cancer may lead to novel therapeutic strategies.
- Highlights the complex interplay between cardiovascular and cancer biology.
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