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Updated: May 18, 2026

Extracellular Glucose Depletion as an Indirect Measure of Glucose Uptake in Cells and Tissues Ex Vivo
Published on: April 6, 2022
[Diabetes mellitus]
Nobuyuki Ura1, Hideki Takizawa, Haruki Sasaki
1Department of General Internal Medicine, Teine Keijinkai Hospital.
Abstract:
Recently renin-angiotensin-aldosterone system (RAAS) including angiotensin converting enzyme (ACE) 2-angiotensin (Ang)-(1-7) system may concern both pancreatic insulin secretion and insulin resistance (IR). Actually, Ang II introduces pancreatic beta-cell apoptosis and suppresses insulin signal transduction by modulation of adipokines. Ang II also suppresses GLUT4 expression and AMP kinase activity. All of them introduce new onset diabetes mellitus and various kinds of diabetic complications. RAAS suppression by using not only ACE inhibitor, Ang II receptor blockade (ARB) but also aldosterone receptor blockade improved insulin secretion and IR. Clinically, ACE inhibitor and ARB suppress new onset diabetes mellitus and diabetic complications. In this review we will focus on the recent findings related RAAS and glucose metabolism and diabetic complications with special reference to ACE2-Ang-(1-7) system.
Insights
The renin-angiotensin-aldosterone system (RAAS) impacts insulin secretion and resistance. RAAS suppression improves glucose metabolism and reduces diabetes complications, highlighting the ACE2-Ang-(1-7) system
Area of Science:
- Endocrinology
- Metabolic Diseases
- Cardiovascular Pharmacology
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