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Updated: May 18, 2026

Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins
Published on: July 8, 2025
[Disease from the point of view of evolution]
Abstract:
In the process of evolution, such compensatory reactions as enhanced reabsorption of sodium chloride and an increase of arterial pressure could be formed only for compensation of acute pathological states (blood loss, dehydration). At present they remain similarly adequate in acute disturbances of blood circulation and of water-electrolyte balance. However, in severe chronic pathology of heart and kidney they often lose their compensatory function and even become dangerous. Evolution of human and of human society has created novel social conditions of adaptation. They are of humanitarian and technogenic character by promoting prevention and treatment of diseases.
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