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Recommended Nordic paediatric reference intervals for 21 common biochemical properties
Linda Hilsted1, Pål Rustad, Lise Aksglæde
1Department of Clinical Biochemistry, Rigshospitalet Copenhagen University Hospital, Copenhagen, Denmark. linda.hilsted@rh.regionh.dk
Scandinavian Journal of Clinical and Laboratory Investigation
|September 28, 2012
Summary
Establishing accurate paediatric reference intervals for 21 biochemical properties in healthy Danish children revealed significant age and gender-related differences, crucial for reliable clinical interpretation.
Area of Science:
- Clinical Biochemistry
- Paediatric Laboratory Medicine
- Reference Interval Determination
Background:
- Establishing paediatric reference intervals is challenging, often relying on data from hospitalized children.
- Published data may exhibit biases due to variations in analytical methods.
Purpose of the Study:
- To establish reliable reference intervals for 21 common biochemical properties in healthy Danish children.
- To address biases in existing paediatric reference data by using standardized methods.
Main Methods:
- Collected blood samples from 1429 healthy Danish children.
- Analyzed 21 biochemical properties using a Roche-Modular-P/ISE-system with NORIP reference material.
- Recalculated reference values using target values of NORIP reference material X.
Main Results:
- Established commutable reference intervals for 20 biochemical properties.
- Reported method-specific reference intervals for LDL-Cholesterol.
- Observed significant age-related differences for most properties and gender-related differences around puberty.
Conclusions:
- The study provides updated, reliable paediatric reference intervals for common biochemicals.
- Age and gender significantly influence biochemical property levels in children.
- These intervals are essential for accurate paediatric health assessment.
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