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Microalbuminuria in adolescents with insulin-dependent diabetes mellitus

J J Cook1, D Daneman

  • 1Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada.

American Journal of Diseases of Children (1960)
|February 1, 1990
PubMed

Insights

Microalbuminuria in adolescents with insulin-dependent diabetes mellitus is linked to poorer metabolic control. Higher albumin excretion rates correlate with elevated hemoglobin A1c, not necessarily higher blood pressure.

Area of Science:

  • Pediatrics
  • Endocrinology
  • Nephrology

Background:

  • Microalbuminuria is an early indicator of diabetic nephropathy.
  • Adolescents with insulin-dependent diabetes mellitus are at risk for kidney complications.

Purpose of the Study:

  • To investigate the prevalence of microalbuminuria in adolescents with insulin-dependent diabetes mellitus.
  • To identify factors associated with microalbuminuria in this population.

Main Methods:

  • Screened 210 adolescents (aged 12-18) with insulin-dependent diabetes mellitus for microalbuminuria.
  • Assessed albumin excretion rate, blood pressure, disease duration, and hemoglobin A1c levels.

Main Results:

  • 16% of adolescents exhibited persistent microalbuminuria.
  • No significant differences in age, sex, disease duration, or recent blood pressure were found between groups.
  • A positive correlation was observed between log albumin excretion rate and mean hemoglobin A1c over 3 years.

Conclusions:

  • Poorer metabolic control (higher HbA1c) is associated with increased albumin excretion rate in adolescents with diabetes.
  • Elevated systemic blood pressure may not consistently precede the development of microalbuminuria.

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