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Radiation-induced enteropathy.

M E Sher1, J Bauer

  • 1Department of Surgery, Mount Sinai Hospital, New York, NY.

The American Journal of Gastroenterology
|February 1, 1990
PubMed
Summary
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Chronic radiation enteritis is increasing with radiotherapy use. This review covers its causes, progression, and management, including surgical resection for severe cases.

Area of Science:

  • Gastroenterology
  • Oncology
  • Radiation Oncology

Background:

  • Rising incidence of chronic radiation enteritis linked to increased radiotherapy for abdominal/pelvic cancers.
  • Understanding the etiology, pathogenesis, and management of radiation enteritis is crucial.

Observation:

  • Two case reports illustrate the progressive nature of radiation enteritis.
  • Case 1: Small bowel obstruction 10 years post-radiotherapy, requiring surgery.
  • Case 2: Acute perforation with a 14-year latency period.

Findings:

  • Predisposing factors for progression include excessive radiation, cardiovascular disease, bowel fixation, and asthenic habitus.
  • Surgical resection with primary anastomosis effectively removes diseased bowel, preventing complications like bleeding or fistulas.

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Implications:

  • Current knowledge on radiation enteritis can guide improved treatment and prevention strategies.
  • Early identification and management of risk factors may mitigate disease progression.