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Updated: May 18, 2026
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Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss
Published on: January 25, 2016
Proinflammatory cytokine IL-1 β polymorphisms in sudden sensorineural hearing loss
Jae-Young Um1, Chul-Ho Jang, Hye-Lin Kim
1College of Korean Medicine, Institute of Korean Medicine, Kyung Hee University, 1 Heogi-dong, Dongdaemun-gu, Seoul, Republic of Korea. jyum@khu.ac.kr
Immunopharmacology and Immunotoxicology
|September 28, 2012
Summary
Interleukin-1 beta (IL-1β) gene variations are linked to sudden sensorineural hearing loss (SSNHL). Specific IL-1β polymorphisms increase the risk, suggesting a role in SSNHL development.
Area of Science:
- Genetics
- Otolaryngology
- Immunology
Background:
- Sudden sensorineural hearing loss (SSNHL) pathogenesis is not fully understood.
- Interleukin-1 beta (IL-1β) is a potent inflammatory cytokine implicated in various diseases.
Purpose of the Study:
- To investigate the association between IL-1β gene polymorphisms (-511 C/T and +3953 C/T) and SSNHL.
- To evaluate the role of IL-1β genetic variations in the etiopathogenesis of SSNHL.
Main Methods:
- Genotyping of 102 SSNHL patients and 595 controls for IL-1β gene polymorphisms (-511 C/T and +3953 C/T).
- Analysis using polymerase chain reaction amplification and DNA fragment electrophoresis.
Main Results:
- A significant association was found between specific IL-1β polymorphisms and SSNHL.
- The IL-1β (+3953) T allele increased SSNHL risk in individuals with the IL-1β (-511) TT genotype (OR = 9.111, p = 0.022).
- Both IL-1β -511 T and +3953 T alleles were carried significantly more often in SSNHL patients compared to controls.
Conclusions:
- IL-1β gene polymorphisms at the -511 and +3953 loci are associated with SSNHL.
- These genetic variations may contribute to the development of SSNHL.
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