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Centronuclear myopathy in a Border collie dog.
S Eminaga1, G B Cherubini, G D Shelton
1Dick White Referrals, Station Farm, Six Mile Bottom, Cambridgeshire, UK.
The Journal of Small Animal Practice
|September 28, 2012
Summary
This study reports the first case of centronuclear/myotubular myopathy in a Border collie, a rare neuromuscular disorder. The affected dog showed clinical improvement with supportive nutritional and vitamin therapy.
Area of Science:
- Veterinary Neurology
- Canine Myopathies
Background:
- Centronuclear myopathy (CNM) and myotubular myopathy (MTM) are congenital muscle diseases characterized by centralized nuclei.
- These conditions are rare in dogs, with limited documented cases.
Observation:
- A two-year-old male Border collie presented with a year-long history of exercise-induced collapse and generalized muscle atrophy.
- Neurological examination indicated a generalized neuromuscular disorder, and electromyography revealed widespread spontaneous muscle electrical activity.
Findings:
- Histopathological, histochemical, and ultrastructural analyses of muscle biopsies were consistent with centronuclear or myotubular myopathy.
- This represents the first documented instance of centronuclear/myotubular myopathy in the Border collie breed.
Implications:
- This case expands the known breed distribution for centronuclear/myotubular myopathy in canines.
- Supportive treatment with L-carnitine, co-enzyme Q10, and vitamin B complex showed positive clinical effects, suggesting potential therapeutic avenues.
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