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Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...

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Related Experiment Video

Updated: May 18, 2026

Venous Thrombosis Assay in a Mouse Model of Cancer

Venous Thrombosis Assay in a Mouse Model of Cancer

Published on: January 5, 2024

Venous thromboembolism in the hematologic malignancies.

Anna Falanga¹, Marina Marchetti, Laura Russo

¹Division of Immunohematology and Transfusion Medicine, Ospedali Riuniti di Bergamo, Bergamo, Italy. annafalanga@yahoo.com

Current Opinion in Oncology

|September 28, 2012

Summary

Patients with hematologic cancers face a high risk of venous thromboembolism (VTE). Prophylaxis is crucial but lacks clear guidelines, except for multiple myeloma, necessitating further research.

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Deep Vein Thrombosis Induced by Stasis in Mice Monitored by High Frequency Ultrasonography

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Published on: April 13, 2018

Area of Science:

Hematology
Oncology
Thrombosis Research

Background:

Hematologic malignancies significantly increase the risk of thrombotic complications.
Venous thromboembolism (VTE) incidence varies based on disease type, stage, therapies, and central venous device use.

Purpose of the Study:

To review current knowledge on venous thromboembolism (VTE) epidemiology, prophylaxis, and treatment in lymphoma, multiple myeloma, and acute leukemia patients.
To highlight the impact of VTE on morbidity and mortality in hematologic cancer patients.

Main Methods:

Literature review summarizing epidemiological data.
Analysis of factors influencing VTE incidence in hematologic malignancies.
Evaluation of current prophylaxis and treatment strategies.

Main Results:

Hematologic cancers are associated with a high risk of VTE.
Chemotherapy, immunomodulating agents, and steroids exacerbate thrombosis risk, particularly in acute leukemia, lymphoma, and multiple myeloma.
Central venous device use is a significant contributing factor to VTE.

Conclusions:

Thrombotic complications significantly impact hematologic cancer patient outcomes.
Clear thromboprophylaxis recommendations are lacking for most hematologic malignancies, except multiple myeloma.
Large prospective randomized trials are needed to establish best practices for VTE prevention and treatment in these patients.