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Longitudinal decline in lung function in former asbestos exposed workers.

Eduardo Algranti¹, Elizabete Medina Coeli Mendonça, Eva Hnizdo

¹Division of Medicine, FUNDACENTRO, Sao Paulo, Brazil. eduardo@fundacentro.gov.br

Occupational and Environmental Medicine

|September 28, 2012

Summary

Occupational asbestos exposure accelerates lung function decline, particularly when combined with smoking. This effect is most pronounced during the working years for asbestos-cement industry workers.

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Area of Science:

Occupational Health
Pulmonary Medicine
Environmental Health

Background:

Asbestos exposure is a known occupational hazard.
Longitudinal lung function decline is a critical measure of respiratory health.

Purpose of the Study:

To assess the impact of asbestos exposure on the rate of lung function decline.
To investigate the relationship between occupational asbestos exposure and changes in FEV1 and FVC over time.

Main Methods:

Study included 502 asbestos-cement workers with longitudinal spirometry data.
Mixed-effects models analyzed the effect of exposure on lung function levels and decline rates.
Evaluations included respiratory questionnaires, spirometry, and chest imaging.

Main Results:

Asbestos exposure and smoking were associated with lower lung function levels.
Asbestos exposure did not significantly increase the rate of FEV1 and FVC decline.
Combined effects of smoking and asbestos exposure accelerated lung function decline.

Conclusions:

Occupational asbestos exposure is a risk factor for accelerated lung function decline.
The detrimental effects of asbestos exposure on lung function are amplified by smoking.
Interventions should focus on reducing combined exposures during the working period.