Related Experiment Video
Updated: May 18, 2026

Transcutaneous Assessment of Renal Function in Conscious Rodents
Published on: March 26, 2016
Measuring glomerular filtration rate in acute kidney injury: yes, but not yet
Abstract:
Acute kidney injury has become a major focus for nephrologists and critical care physicians. The development of structural biomarkers is proceeding, but the results to date have been disappointing. The use of a shortened creatinine clearance as a functional acute kidney injury biomarker is not new but has not been compared with that of other diagnostic approaches. A rapid, repeatable, and accurate measured glomerular filtration rate would be the gold standard for a functional biomarker and is not far off.
Related Concept Videos
Drug Dosing in Renal Diseases: Measurement of Glomerular Filtration Rate
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration
Acute Kidney Injury IV: Diagnostic Studies and Prevention
Acute Kidney Injury III: Clinical Manifestations
Acute Kidney Injury I: Introduction
Renal Clearance
Renal clearance refers to the volume of plasma cleared of a specific substance, such as creatinine, per unit of time. To measure clearance, urine samples are collected over a 24-hour period during each bladder voiding, followed by a single blood sample at the...

