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Updated: May 18, 2026
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Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
Published on: November 12, 2015
Collagen cross-linking for resistant corneal ulcer.
Rana Sorkhabi1, Mohamadreza Sedgipoor, Ali Mahdavifard
1Tabriz University of Medical Sciences, Tabriz, Iran. sorkhabi_r@yahoo.com
International Ophthalmology
|September 28, 2012
Summary
Corneal collagen cross-linking effectively treats resistant corneal ulcers when antibiotics fail. This innovative approach promotes healing and improves vision in most patients, offering a viable alternative treatment.
Area of Science:
- Ophthalmology
- Corneal Disease Research
- Regenerative Medicine
Background:
- Corneal ulcers are sight-threatening conditions often managed with antibiotics or keratoplasty.
- Resistant corneal ulcers pose a significant clinical challenge, necessitating alternative therapeutic strategies.
Purpose of the Study:
- To evaluate the efficacy of corneal collagen cross-linking (CXL) as a treatment for infectious corneal ulcers resistant to conventional therapies.
Main Methods:
- Ten patients with recalcitrant infectious corneal ulcers received standard corneal collagen cross-linking (CXL) using riboflavin and UV-A.
- Patients were monitored post-procedure for healing, visual outcomes, and complications.
Main Results:
- Successful healing and scar formation were observed in the majority of patients.
- Significant visual improvement was noted in most cases, with two patients requiring enucleation or tectonic penetrating keratoplasty.
Conclusions:
- Corneal collagen cross-linking (CXL) is a promising therapeutic option for managing resistant corneal ulcers.
- CXL can serve as an effective adjuvant therapy, enhancing conventional treatment protocols for challenging corneal ulcer cases.
