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Related Experiment Video

Updated: May 18, 2026

Doppler Optical Coherence Tomography of Retinal Circulation
10:46

Doppler Optical Coherence Tomography of Retinal Circulation

Published on: September 18, 2012

A new laser Doppler system for examining optic nerve head circulation.

A Yoshida, G T Feke, G D Feke

    Journal of Biomedical Optics
    |September 28, 2012
    PubMed
    Summary

    A novel laser Doppler system noninvasively measures optic nerve head microcirculation blood flow speed. This rapid, computer-controlled system offers quantitative results suitable for clinical use.

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    Area of Science:

    • Ophthalmology
    • Biomedical Engineering
    • Medical Optics

    Background:

    • Microcirculation in the optic nerve head is crucial for maintaining vision.
    • Noninvasive methods for assessing optic nerve head blood flow are needed for early disease detection.

    Purpose of the Study:

    • To describe a new laser Doppler system for noninvasive examination of human optic nerve head microcirculation.
    • To evaluate the system's speed, quantitative capabilities, and clinical applicability.

    Main Methods:

    • A modified retinal camera with laser optics and fiber optics for Doppler-shifted light detection was used.
    • Real-time data acquisition under computer control enabled automated analysis.
    • The system quantified the speed of blood cells in optic nerve head capillaries.

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    Last Updated: May 18, 2026

    Doppler Optical Coherence Tomography of Retinal Circulation
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    Published on: September 18, 2012

    Using Laser Doppler Imaging and Monitoring to Analyze Spinal Cord Microcirculation in Rat
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    Main Results:

    • The system provides quantitative measurements of blood cell speed in optic nerve head capillaries.
    • Results are available within minutes of data acquisition, making it clinically practical.
    • Multiple measurements showed a coefficient of variation of 8.9%, indicating good reproducibility.

    Conclusions:

    • This new laser Doppler system offers a rapid and noninvasive method for assessing optic nerve head microcirculation.
    • Its quantitative output and speed make it suitable for routine clinical application.
    • The system aids in the evaluation of conditions affecting optic nerve head blood flow.