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Updated: May 18, 2026

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
Nitric oxide donor-based platinum complexes as potential anticancer agents
Jian Zhao1, Shaohua Gou, Yanyan Sun
1Pharmaceutical Research Center, School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, PR China.
Abstract:
Joining forces: Platinum complexes containing organic nitrate ligands were investigated as anticancer agents. The complexes, which were stable in aqueous solution, showed cytotoxicity that was superior to that of the corresponding parent compound (carboplatin), thus suggesting an interesting synergy between the ability of the nitrate-based ligands to release nitric oxide and the ability of the platinum moiety to inhibit DNA synthesis (see scheme).
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