Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 18, 2026

Manipulation of Single Neural Stem Cells and Neurons in Brain Slices using Robotic Microinjection
11:40

Manipulation of Single Neural Stem Cells and Neurons in Brain Slices using Robotic Microinjection

Published on: January 21, 2021

Cellular-level surgery using nano robots.

Bo Song1, Ruiguo Yang, Ning Xi

  • 1Department of Electrical and Computer Engineering, Michigan State University, East Lansing, Michigan 48824, USA.

Journal of Laboratory Automation
|September 28, 2012
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Unraveling the Raman Enhancement Mechanism on 1T'-Phase ReS<sub>2</sub> Nanosheets.

Small (Weinheim an der Bergstrasse, Germany)·2018
Same author

Impact of overexpression of cytosolic isoform of O-acetylserine sulfhydrylase on soybean nodulation and nodule metabolome.

Scientific reports·2018
Same author

Heavy metal contents and enrichment characteristics of dominant plants in wasteland of the downstream of a lead-zinc mining area in Guangxi, Southwest China.

Ecotoxicology and environmental safety·2018
Same author

Quantitative Monitoring and Visualization of Hydrogen Sulfide In Vivo Using a Luminescent Probe Based on a Ruthenium(II) Complex.

Angewandte Chemie (International ed. in English)·2018
Same author

Accurate virial coefficients of gaseous krypton from state-of-the-art ab initio potential and polarizability of the krypton dimer.

The Journal of chemical physics·2018
Same author

Reversible colour change in leaves enhances pollinator attraction and reproductive success in Saururus chinensis (Saururaceae).

Annals of botany·2018
Same journal

Current Trends in Multidrug Optimization.

Journal of laboratory automation·2017
Same journal

From the Editor-in-Chief: The 2013 JALA Ten: Call for Nominations.

Journal of laboratory automation·2017
Same journal

From the Editor-in-Chief: The JALA Special Issues on Robotics in Laboratory Automation.

Journal of laboratory automation·2017
Same journal

Informatics and Computing.

Journal of laboratory automation·2017
Same journal

Informatics and Computing.

Journal of laboratory automation·2017
Same journal

Automated Systems.

Journal of laboratory automation·2017
See all related articles

We introduce a novel atomic force microscope (AFM)-based nanorobot for precise cellular surgery. This nanorobot enables advanced imaging, manipulation, drug delivery, and real-time monitoring of living samples.

Area of Science:

  • Nanotechnology
  • Biophysics
  • Microscopy

Background:

  • Atomic Force Microscopy (AFM) is crucial for nanoscale imaging and mechanical property analysis.
  • Existing AFM techniques have limitations in manipulating and performing surgery on living biological samples at the cellular level.

Purpose of the Study:

  • To propose and conceptualize a novel AFM-based nanorobot for advanced applications in cellular-level surgery.
  • To integrate multiple functionalities including imaging, manipulation, mechanical characterization, and targeted drug delivery.

Main Methods:

  • Development of a versatile nanorobot platform utilizing AFM technology.
  • Incorporation of tip functionalization for precise local drug delivery.
  • Implementation of a "videolized" visual feedback system for real-time monitoring.

More Related Videos

Robotics in Surgery: A Modular Robotic Platform Driven Gastric Wedge Resection
07:27

Robotics in Surgery: A Modular Robotic Platform Driven Gastric Wedge Resection

Published on: February 7, 2025

Folding and Characterization of a Bio-responsive Robot from DNA Origami
07:59

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Published on: December 3, 2015

Related Experiment Videos

Last Updated: May 18, 2026

Manipulation of Single Neural Stem Cells and Neurons in Brain Slices using Robotic Microinjection
11:40

Manipulation of Single Neural Stem Cells and Neurons in Brain Slices using Robotic Microinjection

Published on: January 21, 2021

Robotics in Surgery: A Modular Robotic Platform Driven Gastric Wedge Resection
07:27

Robotics in Surgery: A Modular Robotic Platform Driven Gastric Wedge Resection

Published on: February 7, 2025

Folding and Characterization of a Bio-responsive Robot from DNA Origami
07:59

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Published on: December 3, 2015

Main Results:

  • The proposed nanorobot integrates imaging, manipulation, mechanical property characterization, and tracking capabilities.
  • Tip functionalization enables precise local drug delivery for complex nano-surgery on cells and bacteria.
  • User-friendly "videolized" feedback allows simultaneous surgery operation and result observation.

Conclusions:

  • The AFM-based nanorobot offers a powerful tool for intricate nano-surgery on living samples.
  • The system's modular design allows for integration with additional modules for expanded property characterization (e.g., local conductance, capacitance).
  • This technology has significant potential for advancing research and applications in cell biology and nanomedicine.