Related Experiment Video
Updated: May 18, 2026

09:14
A Mouse Model of Ankle-Subtalar Complex Joint Instability
Published on: October 28, 2022
Mechanical joint laxity associated with chronic ankle instability: a systematic review
Mitchell L Cordova1, Joellen M Sefton, Tricia J Hubbard
1Biodynamics Research Laboratory, Department of Kinesiology and Center for Biomedical Engineering Systems, University of North Carolina at Charlotte, Charlotte, North Carolina.
Sports Health
|September 28, 2012
Summary
Chronic ankle instability (CAI) significantly impacts inversion and anterior joint laxity, reflecting initial injury mechanisms. This systematic review quantifies CAI
Area of Science:
- Orthopedics
- Sports Medicine
- Biomechanics
Background:
- Untreated lateral ankle sprains can lead to chronic mechanical joint laxity.
- Joint laxity is commonly assessed using manual stress tests, stress radiography, and instrumented ankle arthrometers.
Purpose of the Study:
- To systematically review existing literature and determine the effect of chronic ankle instability (CAI) on sagittal and frontal plane mechanical joint laxity.
Main Methods:
- A comprehensive literature search was conducted using MEDLINE, CINAHL, and the Cochrane Database of Systematic Reviews.
- Included studies were case-controlled, measured mechanical joint laxity using specific devices, assessed anteroposterior inversion/eversion laxity, and provided group means and standard deviations.
- Eight studies were included in the final analysis after initial screening of 1378 articles, with quality assessed using the PEDro scale.
Main Results:
- Chronic ankle instability (CAI) demonstrated the most significant effect on inversion joint laxity, with effect sizes ranging from 0.84 to 2.61.
- Anterior joint laxity was the second most affected by CAI, with effects ranging from 0.32 to 1.82.
- CAI had a less pronounced influence on posterior and eversion joint laxity measurements.
Conclusions:
- Chronic ankle instability (CAI) exerts the greatest influence, with the highest variability, on anterior and inversion joint laxity.
- These findings align with the typical mechanisms involved in the initial ankle sprain injury.
Related Concept Videos
Ankle Joint
The ankle is formed by the talocrural joint (crural = leg). It consists of the articulations between the talus bone of the foot and the distal ends of the tibia and fibula of the leg. The superior aspect of the talus bone is square-shaped and has three areas of articulation. The top of the talus articulates with the inferior tibia. This is the portion of the ankle joint that carries the body weight between the leg and foot. The sides of the talus are firmly held in position by the articulations...
Structural Joints: Synovial Joints
Synovial joints are the most common type of joint in the body. A key structural characteristic for a synovial joint is the presence of a joint cavity. This fluid-filled space is where the articulating surfaces of the bones contact each other. Also, unlike fibrous or cartilaginous joints, the articulating bone surfaces at a synovial joint are not directly connected to each other with fibrous connective tissue or cartilage. This gives the bones of a synovial joint the ability to move smoothly...
Development of the Limb Synovial Joints
Joints form during embryonic development in conjunction with the formation and growth of the associated bones. The embryonic tissue that gives rise to all bones, cartilage, and connective tissues of the body is called mesenchyme.
The mesenchymal stem cells differentiate into chondrocytes that form the hyaline cartilage, and later the cartilaginous model of the bone. This model further transforms into a bone. This process is known as endochondral ossification.
During development, the limbs...
The mesenchymal stem cells differentiate into chondrocytes that form the hyaline cartilage, and later the cartilaginous model of the bone. This model further transforms into a bone. This process is known as endochondral ossification.
During development, the limbs...
Knee Joint
The knee joint is the most complicated joint in the body. It consists of three articulations– two tibiofemoral and one patellofemoral. As is characteristic of synovial joints, the knee joint has a thin articular capsule that partially surrounds this joint cavity. Additionally, several ligaments, muscles, and cartilaginous structures support the movement of the knee.
A total of seven ligaments support the knee joint. The patellar ligament, which is also attached to the quadriceps femoris group...
A total of seven ligaments support the knee joint. The patellar ligament, which is also attached to the quadriceps femoris group...

